High-dose methotrexate in children with acute lymphoblastic leukemia: 7-hydroxymethotrexate systemic exposure and urinary concentrations at the steady state correlate well with those of methotrexate

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F10%3A10070071" target="_blank" >RIV/00216208:11150/10:10070071 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/10:10070071

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

High-dose methotrexate in children with acute lymphoblastic leukemia: 7-hydroxymethotrexate systemic exposure and urinary concentrations at the steady state correlate well with those of methotrexate

Original language description

The present study evaluated the pharmacokinetics of methotrexate (MTX, CAS 59-O5-2) and 7-hydroxymethotrexate (7-OHMTX, CAS 5939-37-7) in children with acute lymphoblastic leukemia (ALL). The steady-state renal CLs, total CLs as well as urinary concentrations of the parent compound and metabolite are highly correlated and the correlation of plasma concentrations is moderate. Therefore, it is unlikely that simultaneous evaluation of 7-OHMTX and MTX steady-state concentrations could improve the predictiveperformance.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FG - Paediatrics

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Arzneimittel-Forschung/Drug Research

ISSN

0004-4172

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

12

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

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UT code for WoS article

000285797400005

EID of the result in the Scopus database

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