Activation of B cell apoptotic pathways in the course of Francisella tularensis infection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F10%3A10082167" target="_blank" >RIV/00216208:11150/10:10082167 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/10:00002233 RIV/00216208:11160/10:00300653

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Activation of B cell apoptotic pathways in the course of Francisella tularensis infection

Original language description

Francisella tularensis is a facultative intracellular, gram-negative bacterium that induces apoptosis in macrophages and B cells. Here we show apoptotic pathways that are activated in the Ramos human B cell line in the course of F. tularensis infection.Live bacteria E tularensis FSC200 activate caspases 8, 9 and 3, as well as Bid; release cytochrome c and apoptosis-inducing factor from mitochondria; and induce depolarization of mitochondrial membrane potential in the Ramos cell line, thus leading thesecells to apoptosis. Unlike live bacteria, killed F. tularensis FSC200 bacteria activated only caspase 3, and did not cause apoptosis of Ramos cells as measured by annexin V. Killed bacteria also caused accumulation of anti-apoptotic protein Bclx(L) in mitochondrial membranes. Thus, live F. tularensis activates both caspase pathways (receptor-mediated and intrinsic) as well as caspase-independent mitochondrial death.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/GA310%2F07%2F0226" target="_blank" >GA310/07/0226: Study of B-cell interaction with intracellular pathogen Francisella tularensis.</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Microbial Pathogenesis

ISSN

0882-4010

e-ISSN

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Volume of the periodical

49

Issue of the periodical within the volume

5

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

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UT code for WoS article

000281124100003

EID of the result in the Scopus database

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