Proteomic insights into chronic anthracycline cardiotoxicity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10099465" target="_blank" >RIV/00216208:11150/11:10099465 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/11:10099465 RIV/60162694:G44__/11:00002570
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0022282811000587" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0022282811000587</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.yjmcc.2011.01.018" target="_blank" >10.1016/j.yjmcc.2011.01.018</a>
Alternative languages
Result language
angličtina
Original language name
Proteomic insights into chronic anthracycline cardiotoxicity
Original language description
In this study, global molecular changes associated with chronic anthracycline cardiotoxicity were analyzed for the first time using proteomic techniques. This approach identified 47 proteins significantly changed due to the treatment. Important changes were found in mitochondrial oxidative phosphorylation and energy channeling, intermediate filament desmin, myosin light chains, proteolytic systems, chaperon proteins and many others. Furthermore, basement membrane and extracellular matrix remodeling wasdocumented. The above described changes were corroborated with other molecular and biochemical methods. Hence, in this study the proteomic signature of chronic anthracycline cardiotoxicity was described and it enhances understanding to the molecular basis of this iatrogenic disease.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA305%2F09%2F0416" target="_blank" >GA305/09/0416: Myocardial damage induced by anticancer drugs and ischemia-reperfusion: new possibilities of pharmacological cardioprotection.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular and Cellular Cardiology
ISSN
0022-2828
e-ISSN
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Volume of the periodical
50
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
849-862
UT code for WoS article
000289748200012
EID of the result in the Scopus database
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