The endocannabinoid system in sepsis - a potential target to improve microcirculation?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10103759" target="_blank" >RIV/00216208:11150/11:10103759 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/11:10103759
Result on the web
<a href="http://www.signavitae.com/attachments/SIGNA%20VITAE%202011%206%281%29%207%20-%2013.pdf" target="_blank" >http://www.signavitae.com/attachments/SIGNA%20VITAE%202011%206%281%29%207%20-%2013.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The endocannabinoid system in sepsis - a potential target to improve microcirculation?
Original language description
During the last decade, research has identified the endocannabinoid system (ECS) as a key regulator of essential physiological functions, including the regulation of micro vascular and immune function. Indeed, increasing evidence now suggests that release of endocannabinoids and activation of cannabinoid receptors occurs during sepsis and that manipulation of the ECS may represent an important therapeutic target to improve microcirculation in sepsis. In this review, the pharmacology and physiology of the ECS and the involvement of cannabinoids, cannabinoid receptors and non-CB1R/CB2R pathways related to ECS activation will be described. This information will increase our comprehension of the role of lipid signaling pathways in sepsis and may lead to the identification of new drug targets for the treatment of impaired microcirculation.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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