All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Cannabinoid receptor 1 inhibition improves the intestinal microcirculation in experimental endotoxemia

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10290056" target="_blank" >RIV/00179906:_____/14:10290056 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11150/14:10290056

  • Result on the web

    <a href="http://dx.doi.org/10.3233/CH-131668" target="_blank" >http://dx.doi.org/10.3233/CH-131668</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3233/CH-131668" target="_blank" >10.3233/CH-131668</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cannabinoid receptor 1 inhibition improves the intestinal microcirculation in experimental endotoxemia

  • Original language description

    INTRODUCTION: Impairment of the intestinal microcirculation in endotoxemia may cause a deterioration of the mucosal barrier function thus releasing intraluminal bacteria and their toxins into the systemic circulation. In clinical sepsis this mechanism may influence disease severity and outcome. The aim of the study was to investigate the impact of cannabinoid receptor 1 (CB1R) modulation within the intestinal microcirculation with regard to leukocyte activation and capillary perfusion, and on intestinalhistology in experimental endotoxemia in rats.CONCLUSIONS: CB1R inhibition significantly improved intestinal microcirculation by reducing leukocyte adhesion and increasing FCD in acute endotoxemia in rats. The data supports the involvement of the CB1R signaling in leukocyte activation during sepsis. Drugs targeting the CB1R may have therapeutic potential in systemic inflammation, such as sepsis.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Hemorheology and Microcirculation

  • ISSN

    1386-0291

  • e-ISSN

  • Volume of the periodical

    58

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    10

  • Pages from-to

    333-342

  • UT code for WoS article

    000346271800004

  • EID of the result in the Scopus database