Cannabinoid receptor 1 inhibition improves the intestinal microcirculation in experimental endotoxemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10290056" target="_blank" >RIV/00179906:_____/14:10290056 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/14:10290056
Result on the web
<a href="http://dx.doi.org/10.3233/CH-131668" target="_blank" >http://dx.doi.org/10.3233/CH-131668</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/CH-131668" target="_blank" >10.3233/CH-131668</a>
Alternative languages
Result language
angličtina
Original language name
Cannabinoid receptor 1 inhibition improves the intestinal microcirculation in experimental endotoxemia
Original language description
INTRODUCTION: Impairment of the intestinal microcirculation in endotoxemia may cause a deterioration of the mucosal barrier function thus releasing intraluminal bacteria and their toxins into the systemic circulation. In clinical sepsis this mechanism may influence disease severity and outcome. The aim of the study was to investigate the impact of cannabinoid receptor 1 (CB1R) modulation within the intestinal microcirculation with regard to leukocyte activation and capillary perfusion, and on intestinalhistology in experimental endotoxemia in rats.CONCLUSIONS: CB1R inhibition significantly improved intestinal microcirculation by reducing leukocyte adhesion and increasing FCD in acute endotoxemia in rats. The data supports the involvement of the CB1R signaling in leukocyte activation during sepsis. Drugs targeting the CB1R may have therapeutic potential in systemic inflammation, such as sepsis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Hemorheology and Microcirculation
ISSN
1386-0291
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
333-342
UT code for WoS article
000346271800004
EID of the result in the Scopus database
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