Physostigmine reverses disturbances of the intestinal microcirculation during experimental endotoxemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10281562" target="_blank" >RIV/00179906:_____/14:10281562 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/14:10281562
Result on the web
<a href="http://dx.doi.org/10.3233/CH-131743" target="_blank" >http://dx.doi.org/10.3233/CH-131743</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/CH-131743" target="_blank" >10.3233/CH-131743</a>
Alternative languages
Result language
angličtina
Original language name
Physostigmine reverses disturbances of the intestinal microcirculation during experimental endotoxemia
Original language description
Intestinal microcirculatory disturbances play an important role in the pathophysiology of sepsis. A neural anti-inflammatory pathway has been suggested as a potential target for therapy that may dampen systemic inflammation. The aim of this study is to investigate the effects of physostigmine, a cholinesterase inhibitor, on the intestinal microcirculation and vascular contractility in experimental endotoxemia. Endotoxemia was induced in Lewis rats by intravenous lipopolysaccharide (LPS) administration.Animals were treated with either physostigmine or saline (control) following LPS challenge. The intestinal microcirculation, including leukocyte-endothelial interaction, functional capillary density (FCD) and non-perfused capillary density (NCD), was examined by intravital microscopy (IVM) 2 hours after LPS administration. The impact of physostigmine on vascular contractility of rat aortic rings was examined by in vitro myography. Physostigmine significantly reduced the number of adherin
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Hemorheology and Microcirculation
ISSN
1386-0291
e-ISSN
—
Volume of the periodical
56
Issue of the periodical within the volume
3
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
12
Pages from-to
273-284
UT code for WoS article
000334341800009
EID of the result in the Scopus database
—