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Physostigmine reverses disturbances of the intestinal microcirculation during experimental endotoxemia

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10281562" target="_blank" >RIV/00179906:_____/14:10281562 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11150/14:10281562

  • Result on the web

    <a href="http://dx.doi.org/10.3233/CH-131743" target="_blank" >http://dx.doi.org/10.3233/CH-131743</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3233/CH-131743" target="_blank" >10.3233/CH-131743</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Physostigmine reverses disturbances of the intestinal microcirculation during experimental endotoxemia

  • Original language description

    Intestinal microcirculatory disturbances play an important role in the pathophysiology of sepsis. A neural anti-inflammatory pathway has been suggested as a potential target for therapy that may dampen systemic inflammation. The aim of this study is to investigate the effects of physostigmine, a cholinesterase inhibitor, on the intestinal microcirculation and vascular contractility in experimental endotoxemia. Endotoxemia was induced in Lewis rats by intravenous lipopolysaccharide (LPS) administration.Animals were treated with either physostigmine or saline (control) following LPS challenge. The intestinal microcirculation, including leukocyte-endothelial interaction, functional capillary density (FCD) and non-perfused capillary density (NCD), was examined by intravital microscopy (IVM) 2 hours after LPS administration. The impact of physostigmine on vascular contractility of rat aortic rings was examined by in vitro myography. Physostigmine significantly reduced the number of adherin

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FE - Other fields of internal medicine

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Hemorheology and Microcirculation

  • ISSN

    1386-0291

  • e-ISSN

  • Volume of the periodical

    56

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    12

  • Pages from-to

    273-284

  • UT code for WoS article

    000334341800009

  • EID of the result in the Scopus database