Experimental Endotoxemia Induces Leukocyte Adherence and Plasma Extravasation Within the Rat Pial Microcirculation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10103762" target="_blank" >RIV/00216208:11150/11:10103762 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/11:10103762

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/60/60_853.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/60/60_853.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Experimental Endotoxemia Induces Leukocyte Adherence and Plasma Extravasation Within the Rat Pial Microcirculation

Original language description

Disturbance of capillary perfusions due to leukocyte adhesion, disseminated intravascular coagulation, tissue edema is critical components in the pathophysiology of sepsis. Alterations in brain microcirculation during sepsis are not clearly understood. The aim of this study is to gain an improved understanding of alterations through direct visualization of brain microcirculations in an experimental endotoxemia using intravital microscopy (IVM). Endotoxemia was induced in Lewis rats with Lipopolysaccharide (LPS, 15 mg/kg i.v.). The dura mater was removed via a cranial window to expose the pial vessels on the brain surface. Using fluorescence dyes, plasma extravasation of pial venous vessels and leukocyte-endothelial interaction were visualized by intravital microscopy 4 h after LPS administration. Plasma cytokine levels of IL1-beta, IL-6, IFN-gamma, TNF-alpha and KC/GRO were evaluated after IVM. A significant plasma extravasation of the pial venous vessels was found in endotoxemia rats

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

853-859

UT code for WoS article

000299021500002

EID of the result in the Scopus database

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