The Effect of Rat Strain, Diet Composition and Feeding Period on the Development of a Nutritional Model of Non-Alcoholic Fatty Liver Disease in Rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10105379" target="_blank" >RIV/00216208:11150/11:10105379 - isvavai.cz</a>
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/60/60_317.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/60/60_317.pdf</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
The Effect of Rat Strain, Diet Composition and Feeding Period on the Development of a Nutritional Model of Non-Alcoholic Fatty Liver Disease in Rats
Original language description
The aim of this work was to establish and characterize a nutritional model (using a high-fat diet for 3 or 6 weeks) of non-alcoholic fatty liver disease (NAFLD) in male Wistar and Sprague-Dawley rats. Feeding with high fat diet induced small-droplet or mixed hepatic steatosis without focal inflammation and necrosis. We observed changes in liver glutathione levels, malondialdehyde production and expression of UCP-2 mRNA, but not differences in serum biochemical parameters. The present study showed that male Wistar and Sprague-Dawley rats fed by high-fat diet developed comparable simple steatosis without signs of progression to non-alcoholic steatohepatitis.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GP305%2F08%2FP184" target="_blank" >GP305/08/P184: Is the liver affected by non-alcoholic liver disease (NAFLD) more sensitive to toxic injury?</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
—
Volume of the periodical
60
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
12
Pages from-to
317-328
UT code for WoS article
000291154900015
EID of the result in the Scopus database
—