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The role of high-risk human papillomavirus infection in oral and oropharyngeal squamous cell carcinoma in non-smoking and non-drinking patients: a clinicopathological and molecular study of 46 cases

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10105993" target="_blank" >RIV/00216208:11150/11:10105993 - isvavai.cz</a>

  • Alternative codes found

    RIV/00179906:_____/11:10105993

  • Result on the web

    <a href="http://www.ncbi.nlm.nih.gov/pubmed/21221634" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21221634</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00428-010-1037-y" target="_blank" >10.1007/s00428-010-1037-y</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The role of high-risk human papillomavirus infection in oral and oropharyngeal squamous cell carcinoma in non-smoking and non-drinking patients: a clinicopathological and molecular study of 46 cases

  • Original language description

    The aim of the study was to investigate the role of high-risk human papillomavirus (HR-HPV) infection in the etiopathogenesis of oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma in non-smoking and non-drinking patients (NSNDP). Twenty-four OSCCs and 22 OPSCCs were analyzed by immunohistochemistry for p16INK4a protein (p16) expression and by chromogene in situ hybridization (CISH) and polymerase chain reaction (PCR) for HR-HPV DNA presence. The series included 23 males and 23 females aged 35-93 years. p16 expression was seen in 7/24 (29%) OSCCs and in 22/22 (100%) OPSCCs. Using CISH, HR-HPV DNA was observed in 6/24 (25%) OSCCs and in 21/22 (95%) OPSCCs. HPV DNA was found in 3/24 (13%) OSCCs and in 18/22 (82%) OPSCCs using PCR. HPV 16 and 33were detected in 16 and in 2 cases, respectively. Compared with OSCCs, OPSCCs more frequently showed basaloid morphology (p { 0.0001), lymph node involvement (p = 0.0063), diffuse p16 expression (p { 0.0001), HR-HPV DNA presence using bo

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FP - Other medical fields

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Virchows Archiv : an international journal of pathology

  • ISSN

    0945-6317

  • e-ISSN

  • Volume of the periodical

    458

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    9

  • Pages from-to

    179-187

  • UT code for WoS article

    000286830000008

  • EID of the result in the Scopus database