Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16INK4a expression, and HPV status

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10125027" target="_blank" >RIV/00179906:_____/12:10125027 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/12:10125027
Result on the web
<a href="http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=2822&category_id=87&option=com_virtuemart&vmcchk=1&Itemid=1" target="_blank" >http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=2822&category_id=87&option=com_virtuemart&vmcchk=1&Itemid=1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2012_052" target="_blank" >10.4149/neo_2012_052</a>

Result language
angličtina
Original language name
Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16INK4a expression, and HPV status
Original language description
The aim of the study is to evaluate biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma, with emphasis on smoking, protein p16 expression and HPV status. The study sample consisted of 48 patients with OSCC and 44 patients with OPSCC. Half of the patients were nonsmokers. p16 expression was detected in 17/48 OSCCs and in 36/44 OPSCCs and HPV DNA was present in 7/48 OSCCs and in 35/44 OPSCCs. OPSCCs were more frequently basaloid (p < 0.001) while OSCCs were more frequently conventional (p < 0.000001). OSCCs were more likely to recur locally and to be the cause of death (p = 0.009). HPV-positive tumors were more frequently localized in oropharynx, were basaloid SCCs and were p16- and HPV-positive (p < 0.000001). HPV-negative tumors were more frequently localized in oral cavity (p < 0.000001), more frequently associated with locoregional recurrence (p = 0.030) and with tumo
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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