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HPV, protein p16 and squamous cell carcinoma of the oral cavity

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00116360" target="_blank" >RIV/00216224:14110/20:00116360 - isvavai.cz</a>

  • Alternative codes found

    RIV/65269705:_____/20:00073051

  • Result on the web

    <a href="https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2105" target="_blank" >https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2105</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5507/bp.2019.026" target="_blank" >10.5507/bp.2019.026</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    HPV, protein p16 and squamous cell carcinoma of the oral cavity

  • Original language description

    Background: Squamous cell carcinoma of the oral cavity is generally caused by the long-term impact of known risk factors, e.g. tobacco and alcohol, along with chronic traumatisation. A number of studies now implicate HPV infection in head and neck tumour carcinogenesis but the exact role of HPV infection in the oral cavity remains unclear. Methods: In this study, we evaluated 78 patients with oral squamous cell carcinoma (OSCC) for the expression of protein p16 in the context of HPV positivity and its influence on the overall survival rate, disease location, staging and grading. Results: Regarding the tumour location, no significant difference was found between HPV-positive and HPV-negative patients, nor between p16-positive and p16-negative patients. There was also no trend in terms of HPV status and stage, and differentiation of carcinoma. There was no effect on HPV-positive patients relative to the time to progression (P=0.84) and overall survival rate (P=0.78). P16 positivity was not found to have an effect on the overall survival rate of patients (P=0.41) and there was no correlation between p16 positivity relative to the time to progression (P=0.66). Conclusions: In summary, the data suggest that there is no effect of HPV status on the prognosis of OSCC patients compared to other HNSCC locations.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30109 - Pathology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biomedical Papers

  • ISSN

    1213-8118

  • e-ISSN

    1804-7521

  • Volume of the periodical

    164

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    8

  • Pages from-to

    292-299

  • UT code for WoS article

    000595645600011

  • EID of the result in the Scopus database

    2-s2.0-85091173564