Prominin-1 (CD133) is not restricted to stem cells located in the basal compartment of murine and human prostate

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10109261" target="_blank" >RIV/00216208:11150/11:10109261 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1002/pros.21239/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/pros.21239/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/pros.21239" target="_blank" >10.1002/pros.21239</a>

Result language

angličtina

Original language name

Prominin-1 (CD133) is not restricted to stem cells located in the basal compartment of murine and human prostate

Original language description

Rodent and human prominin-1 are expressed in numerous adult epithelia and somatic stem cells. Previous report has shown that human PROMININ-1 carrying the AC133 epitope can be used to identify rare prostate basal stem cells (Richardson et al., J Cell Sci2004; 117:3539-3545). Here we re-investigated its general expression in male reproductive tract including mouse and human prostate and in prostate cancer samples using various anti-prominin-1 antibodies. Murine tissues were stained with 13A4 monoclonalantibody (mAb) whereas human samples were examined either with the AC133 mAb recognizing the AC133 glycosylation-dependent epitope or 80B258 mAb directed against the PROMININ-1 polypeptide. Mouse prominin-1 was detected at the apical domain of epithelialcells of ductus deferens, seminal vesicles, ampullary glands, and all prostatic lobes. In human prostate, immunoreactivity for 80B258, but not AC133 was revealed at the apical side of some epithelial (luminal) cells, in addition to the m

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

—

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Prostate

ISSN

0270-4137

e-ISSN

—

Volume of the periodical

71

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

254-267

UT code for WoS article

000287059600004

EID of the result in the Scopus database

—