Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F12%3A10124113" target="_blank" >RIV/00216208:11150/12:10124113 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/12:10124113
Result on the web
<a href="http://jpet.aspetjournals.org/content/343/2/468.full" target="_blank" >http://jpet.aspetjournals.org/content/343/2/468.full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1124/jpet.112.198358" target="_blank" >10.1124/jpet.112.198358</a>
Alternative languages
Result language
angličtina
Original language name
Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways
Original language description
This article deals with the study of mechanisms responsible for development of chronic anthracycline cardiotoxicity with respect to potential role of the Nrf2 (master regulator of antioxidant defense) and PGC1alfa (master regulator of mitochondrial biogenesis pathway). Our data suggest that there is no coordinated response of Nrf2 pathway in anthracycline cardiotoxicity, while mitochondrial biogenesis seemed rather suppressed, especially in the follow up period.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA305%2F09%2F0416" target="_blank" >GA305/09/0416: Myocardial damage induced by anticancer drugs and ischemia-reperfusion: new possibilities of pharmacological cardioprotection.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pharmacology and Experimental Therapeutics
ISSN
0022-3565
e-ISSN
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Volume of the periodical
343
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
468-478
UT code for WoS article
000309979400024
EID of the result in the Scopus database
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