Cannabinoid Receptor 1 Inhibition Causes Seizures During Anesthesia Induction in Experimental Sepsis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F12%3A10127014" target="_blank" >RIV/00216208:11150/12:10127014 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1213/ANE.0b013e318251dada" target="_blank" >http://dx.doi.org/10.1213/ANE.0b013e318251dada</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1213/ANE.0b013e318251dada" target="_blank" >10.1213/ANE.0b013e318251dada</a>
Alternative languages
Result language
angličtina
Original language name
Cannabinoid Receptor 1 Inhibition Causes Seizures During Anesthesia Induction in Experimental Sepsis
Original language description
We report on seizures during anesthesia induction in animals treated with a cannabinoid receptor 1 (CB1R) antagonist for experimental sepsis. Animals received surgery for colon ascendens stent peritonitis-induced sepsis or sham surgery followed by treatment of CB1R antagonist, CB1R agonist, or placebo. Fourteen hours later, animals received pentobarbital or ketamine for anesthesia induction and animal behavior was observed. Tonic-clonic seizures were observed in 5 of 12 septic animals (42%) treated withCB1R antagonist after induction of anesthesia with pentobarbital. The data suggest that CB1R inhibition in combination with pentobarbital may increase the incidence of anesthetic-induced seizures in the case of sepsis. (Anesth Analg 2012;114:1217-9)
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anesthesia and Analgesia
ISSN
0003-2999
e-ISSN
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Volume of the periodical
114
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
1217-1219
UT code for WoS article
000304504000012
EID of the result in the Scopus database
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