Comparative pharmacokinetics of N-omega-hydroxy-nor-L-arginine, an arginase inhibitor, after single-dose intravenous, intraperitoneal and intratracheal administration to brown Norway rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F13%3A10139304" target="_blank" >RIV/00216208:11150/13:10139304 - isvavai.cz</a>

Result on the web

<a href="http://informahealthcare.com/doi/pdf/10.3109/00498254.2013.780672" target="_blank" >http://informahealthcare.com/doi/pdf/10.3109/00498254.2013.780672</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/00498254.2013.780672" target="_blank" >10.3109/00498254.2013.780672</a>

Result language

angličtina

Original language name

Comparative pharmacokinetics of N-omega-hydroxy-nor-L-arginine, an arginase inhibitor, after single-dose intravenous, intraperitoneal and intratracheal administration to brown Norway rats

Original language description

1.Rodent studies have documented that N-(?)-hydroxy-nor-L-arginine (nor-NOHA), an arginase inhibitor, has therapeutic potential in the treatment of cardiovascular and obstructive airway diseases. However, its bioavailability and pharmacokinetics have notbeen described so far. 2. Anesthetized brown Norway rats were administered single doses of nor-NOHA (10, 30 or 90 mg/kg) intravenously (i.v.), intraperitonealy (i.p.) or via intratracheal (i.t.) instillation of aerosol. Plasma nor-NOHA was assayed usinga validated HPLC method. 3. Upon i.v. administration, the mean concentration showed a biphasic decline and its value dropped below 10% of the maximum after 20 min. The pharmacokinetics were linear with the total and inter-compartmental clearances of 33and 17 mL/min/kg, central and peripheral volumes of distribution of 0.19 and 0.43 L/kg and terminal half-life of 30 min. 4. The average absolute bioavailability of nor-NOHA after i.p. and i.t. delivery was 98% and 53%, respectively. The a

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

"Xenobiotica; the fate of foreign compounds in biological systems"

ISSN

0049-8254

e-ISSN

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Volume of the periodical

43

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

886-894

UT code for WoS article

000324403400006

EID of the result in the Scopus database

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