Single- and multiple-dose pharmacokinetics of arginase inhibitor N-omega-hydroxy-nor-L-arginine, and its effect on plasma amino acids concentrations in Wistar rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10140109" target="_blank" >RIV/00216208:11150/14:10140109 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.4149/gpb_2013078" target="_blank" >http://dx.doi.org/10.4149/gpb_2013078</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/gpb_2013078" target="_blank" >10.4149/gpb_2013078</a>

Result language
angličtina
Original language name
Single- and multiple-dose pharmacokinetics of arginase inhibitor N-omega-hydroxy-nor-L-arginine, and its effect on plasma amino acids concentrations in Wistar rats
Original language description
Arginase inhibitor N-?-hydroxy-nor-L-arginine (nor-NOHA) augments synthesis of nitric oxide (NO) exerting therapeutic effects in rodent models for cardiovascular and airway diseases. This study examined single- and multiple-dose pharmacokinetics and effects of nor NOHA on plasma amino acids in Wistar rats. Animals were administered 30 mg/kg nor NOHA in a single bolus intravenous (i.v.) or intraperitoneal (i.p.) injection, or five once-daily i.p. injections at the same dose, or vehicle. Nor-NOHA and amino acids were assayed in blood plasma by high-performance liquid chromatography. After a bolus i.v. injection, the elimination of nor-NOHA was rapid (the mean residence time=12.5 min). The area under the concentration-time curve and maximum concentrationwere higher by 17% and 31%, respectively, after the fifth as compared to the first i.p. injection. A shift in arginine utilization towards the synthesis of NO was indicated by elevated citrulline-to-ornithine and citrulline-to-arginine ra
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/EE2.3.30.0022" target="_blank" >EE2.3.30.0022: Support of establishment, development, and mobility of quality research teams at the Charles University</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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