Epigallocatechin Gallate Does Not Accelerate the Early Phase of Liver Regeneration After Partial Hepatectomy in Rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10210604" target="_blank" >RIV/00216208:11150/14:10210604 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs10620-013-2966-5" target="_blank" >http://link.springer.com/article/10.1007%2Fs10620-013-2966-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10620-013-2966-5" target="_blank" >10.1007/s10620-013-2966-5</a>
Alternative languages
Result language
angličtina
Original language name
Epigallocatechin Gallate Does Not Accelerate the Early Phase of Liver Regeneration After Partial Hepatectomy in Rats
Original language description
Background: Two-thirds partial hepatectomy (PHx) is an established model for the study of liver regeneration after resection. This process is accompanied by oxidative stress. Aims: In our study, we tested the effect of epigallocatechin gallate (EGCG), agreen tea antioxidant, on the early phase of liver regeneration after PHx. Methods: Male Wistar rats were divided into 5 groups: I) laparotomy + water for injections intraperitoneally, II) laparotomy + EGCG 50 mg/kg body weight, III) PHx + water for injections, IV) PHx + EGCG 20 mg/kg, V) PHx + EGCG 50 mg/kg, during 3 consecutive days. The rats were sacrificed 24 hours after surgery. Biochemical analysis of rat sera was performed. Histological samples were stained with hematoxyline-eosine and bromodeoxyuridine (BrdU). In hepatectomized rats, we also measured plasma malondialdehyde, tissue malondialdehyde, glutathione and cytokines levels, the activity of caspases 3/7, expression of genes Nqo-1 and HO-1 at mRNA level, expression of genes
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Digestive Diseases and Sciences
ISSN
0163-2116
e-ISSN
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Volume of the periodical
59
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
976-985
UT code for WoS article
000334748000015
EID of the result in the Scopus database
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