Hypertension and Cardiovascular Remodelling in Rats Exposed to Continuous Light: Protection by ACE-Inhibition and Melatonin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10271858" target="_blank" >RIV/00216208:11150/14:10271858 - isvavai.cz</a>

Result on the web

<a href="http://http:/dx.doi.org/10.1155/2014/703175" target="_blank" >http://http:/dx.doi.org/10.1155/2014/703175</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/703175" target="_blank" >10.1155/2014/703175</a>

Result language

angličtina

Original language name

Hypertension and Cardiovascular Remodelling in Rats Exposed to Continuous Light: Protection by ACE-Inhibition and Melatonin

Original language description

Exposure of rats to continuous light attenuates melatonin production and results in hypertension development. This study investigated whether hypertension induced by continuous light (24 hours/day) exposure induces heart and aorta remodelling and if these alterations are prevented by melatonin or angiotensin converting enzyme inhibitor captopril. Exposure to continuous light led to hypertension, LV hypertrophy and fibrosis, and enhancement of the oxidative load in the LV and aorta. Increase in systolicblood pressure by continuous light exposure was prevented completely by captopril and partially by melatonin. Both captopril and melatonin reduced the wall thickness and cross-sectional area of the aorta and reduced the level of oxidative stress. However, only captopril reduced LV hypertrophy and only melatonin reduced LV hydroxyproline concentration.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mediators of Inflammation

ISSN

0962-9351

e-ISSN

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Volume of the periodical

2014

Issue of the periodical within the volume

July

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

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UT code for WoS article

000339214100001

EID of the result in the Scopus database

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