Lactacystin-Induced Model of Hypertension in Rats: Effects of Melatonin and Captopril
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10362057" target="_blank" >RIV/00216208:11150/17:10362057 - isvavai.cz</a>
Result on the web
<a href="http://www.mdpi.com/1422-0067/18/8/1612" target="_blank" >http://www.mdpi.com/1422-0067/18/8/1612</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms18081612" target="_blank" >10.3390/ijms18081612</a>
Alternative languages
Result language
angličtina
Original language name
Lactacystin-Induced Model of Hypertension in Rats: Effects of Melatonin and Captopril
Original language description
Lactacystin is a proteasome inhibitor that interferes with several factors involved in heart remodelling. The aim of this study was to investigate whether the chronic administration of lactacystin induces hypertension and heart remodelling and whether these changes can be modified by captopril or melatonin. Lactacystin treatment increased systolic blood pressure and induced fibrosis of the left ventricle. NF-κB expression in the LV was increased in all treated groups in the cytoplasm, however, in neither group in the nucleus. Although melatonin had no effect on SBP, only this indolamine (but not captopril) reduced the concentration of insoluble and total collagen in the LV and stimulated the NO-pathway in the lactacystin group. We conclude that chronic administration of lactacystin represents a novel model of hypertension with collagenous rebuilding of the LV, convenient for testing antihypertensive drugs or agents exerting a cardiovascular benefit beyond blood pressure reduction.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
18
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
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UT code for WoS article
000408897400015
EID of the result in the Scopus database
2-s2.0-85026388328