Experimental models of non-alcoholic fatty liver disease in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10271877" target="_blank" >RIV/00216208:11150/14:10271877 - isvavai.cz</a>
Result on the web
<a href="http://www.wjgnet.com/1007-9327/pdf/v20/i26/8364.pdf" target="_blank" >http://www.wjgnet.com/1007-9327/pdf/v20/i26/8364.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3748/wjg.v20.i26.8364" target="_blank" >10.3748/wjg.v20.i26.8364</a>

Result language
angličtina
Original language name
Experimental models of non-alcoholic fatty liver disease in rats
Original language description
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, and it persists at a high prevalence. The pathogenesis of NAFLD is closely related to the metabolic syndrome and insulin resistance. Understanding the pathophysiology and treatment of NAFLD in humans has currently been limited by the lack of satisfactory animal models. The ideal animal model for NAFLD should reflect all aspects of the intricate etiopathogenesis of human NAFLD and the typical histological findings of its different stages. This paper reviews the widely used experimental models of NAFLD in rats. We discuss nutritional, genetic and combined models of NAFLD and their pros and cons. The choice of a suitable animal model for this disease while respecting its limitations may help to improve the understanding of its complex pathogenesis and to discover appropriate therapeutic strategies.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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