Impairment of mitochondrial function of rat hepatocytes by high fat diet and oxidative stress

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10271880" target="_blank" >RIV/00216208:11150/14:10271880 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/14:00428971

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/63/63_271.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/63/63_271.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Impairment of mitochondrial function of rat hepatocytes by high fat diet and oxidative stress

Original language description

Fatty liver disease associated with obesity is an important medical problem and the mechanisms for lipid accumulation in hepatocytes are not fully elucidated yet. Recent findings indicate that mitochondria play an important role in this process. Our dataon hepatocytes in which mitochondria are in contact with other cytosolic structures important for their function, extend observations obtained on isolated mitochondria and confirm inhibition of Complex I activity in hepatocytes isolated from rats fed byhigh fat diet (HFD) compared with controls fed by standard diet (STD). Furthermore we have found that HFD hepatocytes are more sensitive to the peroxidative stress because under these conditions also Complex II activity is disturbed. Therefore in HFD animals decrease of Complex I activity cannot be compensated by Complex II substrates as in STD hepatocytes. Our data indicate that combination of HFD and peroxidative stress potentiates HFD damaging effect of mitochondria because both bran

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/LL1204" target="_blank" >LL1204: Genetic analysis of mitochondrial proteome: Integration of mitochondrial-nuclear epistasis with disease phenotypes in the rat</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

63

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

271-274

UT code for WoS article

000336459800016

EID of the result in the Scopus database

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