Essential oil from Myrica rubra leaves inhibits cancer cell proliferation and induces apoptosis in several human intestinal lines

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10281586" target="_blank" >RIV/00216208:11150/14:10281586 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/14:00432566 RIV/00216208:11160/14:10281586
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0926669014002210" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0926669014002210</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.indcrop.2014.04.018" target="_blank" >10.1016/j.indcrop.2014.04.018</a>

Result language
angličtina
Original language name
Essential oil from Myrica rubra leaves inhibits cancer cell proliferation and induces apoptosis in several human intestinal lines
Original language description
The leaves of Myrica rubra (Sieb. et Zucc), a subtropical Asian fruit tree with traditional use in folk medicines, were extracted by hydrodistillation. The antiproliferative effect of obtained M. rubra essential oil (MEO) was tested in human colon and ileocecal adenocarcinoma cell lines HCT8, SW620, SW480, HT29 and Caco2. Cytostatic drug paclitaxel was used as a positive control. MEO significantly inhibited cell proliferation in concentration-dependent manner in all cell lines. The efficacy of ME differed in individual cell lines, with Caco2 being the most sensitive. In these cells, MEO, IC50 value of 1.5 ?g/mL was obtained using xCelligence system for real-time cell monitoring. In cancer cells, MEO induces apoptosis and caused significant increase ofactivities of initiator as well as effector caspases. Contrary to cancer cells, MEO) did not affect viability of isolated hepatocytes (as a model of normal non-cancerous cells). GC x GC-TOFMS analysis of MEO, chemical composition revealed
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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