The effect of Myrica rubra essential oil and its components alpha-humulene and trans-nerolidol on adhesion and apoptosis of colorectal cancer cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10312977" target="_blank" >RIV/00216208:11150/15:10312977 - isvavai.cz</a>

Result on the web

<a href="http://www.smartscitech.com/index.php/CCM/article/view/1058/pdf_128" target="_blank" >http://www.smartscitech.com/index.php/CCM/article/view/1058/pdf_128</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14800/ccm.1058" target="_blank" >10.14800/ccm.1058</a>

Result language

angličtina

Original language name

The effect of Myrica rubra essential oil and its components alpha-humulene and trans-nerolidol on adhesion and apoptosis of colorectal cancer cells

Original language description

Essential oil from leaves of Myrica rubra (MEO), a subtropical Asian fruit tree with traditional use in folk medicines, had significant antiproliferative effect in several intestinal cancer cell lines. In present study, we tested the influence of MEO andits most effective compounds alpha-humulene and trans-nerolidol on the cell adhesion, expression of adhesion molecules (ICAM-1; E-cadherin; beta-catenin) and apoptotic molecules (NF-kappaB, caspases) in colorectal cancer cell line HT29. All parameters were followed up and compared in presence or absence of pro-inflammatory agent TNFalpha. The results showed that MEO was able to decrease adhesion of colon cancer HT29 cells to collagen. Furthermore MEO, alpha-humulene and trans-nerolidol significantly suppressed adhesion of TNFalpha-induced cells probably due to down-regulation of ICAM-1. Moreover, MEO and alpha-humulene could diminish tumor invasion and metastasis via up-regulation of E-cadherin. In presence of TNFalpha, MEO and trans-n

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Cell &amp; Microenvironment

ISSN

2331-0928

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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