The role of adhesion molecules in acute myeloid leukemia and (hemato)oncology: A systematic review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10293506" target="_blank" >RIV/00216208:11150/15:10293506 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/15:43875256 RIV/00179906:_____/15:10293506

Result on the web

<a href="http://biomed.papers.upol.cz/pdfs/bio/2015/01/01.pdf" target="_blank" >http://biomed.papers.upol.cz/pdfs/bio/2015/01/01.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2014.049" target="_blank" >10.5507/bp.2014.049</a>

Result language

angličtina

Original language name

The role of adhesion molecules in acute myeloid leukemia and (hemato)oncology: A systematic review

Original language description

Background: The treatment of malignancies like acute myeloid leukemia (AML) is often complicated by the heterogeneity of the disease and the mechanisms of the disease progression. This heterogeneity is often not reflected in standard treatment approacheswhich provide predictable outcomes in the majority of patients but fail in individual cases even with high-dose multi-agent chemotherapy regimens and allogeneic stem cell transplantation. Further, the unselective effect of chemotherapy causes high treatment-related toxicity and accelerates the risk of infection during prolonged pancytopenia, preventing further dose escalation. Despite rapid progress in therapeutic strategies, the fatality of high-grade malignancies remains enormous. Objectives: Adhesive interactions trigger signal transduction pathway activation and this prevents the apoptosis of both normal and malignant cells. A correlation between expression of defined adhesion molecules and patient outcome has been found for severa

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

—

Volume of the periodical

159

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

11

Pages from-to

1-11

UT code for WoS article

000351716500002

EID of the result in the Scopus database

2-s2.0-84924513815