The role of cytokines in acute myeloid leukemia: A systematic review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10131561" target="_blank" >RIV/00179906:_____/12:10131561 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/12:43874730 RIV/00216208:11150/12:10131561

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2012.108" target="_blank" >http://dx.doi.org/10.5507/bp.2012.108</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2012.108" target="_blank" >10.5507/bp.2012.108</a>

Result language

angličtina

Original language name

The role of cytokines in acute myeloid leukemia: A systematic review

Original language description

Background. Acute myeloid leukemia (AML) shows a high degree of heterogeneity owing to a variety of mutations and the mechanisms of leukemogenesis. This heterogeneity is often not reflected in standard treatment approaches which while providing predictable outcomes in the majority of patients fail in particular cases even with high-dose multiagent chemotherapy regimens. Further, the unselective effect of chemotherapy leads to high treatment-related toxicity and the enormous risk of infection during prolonged pancytopenia, preventing further dose escalation. Objectives. Cytokines play a role in leukemogenesis, AML cell persistence and treatment outcome. In this review we highlight cytokine dependent mechanisms essential for AML cell survival and the role of single cytokines in leukemogenesis and allogeneic transplantation-related phenomena. Cytokine-related mechanisms of leukemogenesis, AML cell persistence and resistance to chemotherapy are complex. Modulation of the cytokine network c

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, CzechoSK

ISSN

1213-8118

e-ISSN

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Volume of the periodical

156

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

11

Pages from-to

291-301

UT code for WoS article

000312983100002

EID of the result in the Scopus database

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