Ammonia and amino acid profiles in liver cirrhosis: Effects of variables leading to hepatic encephalopathy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10295083" target="_blank" >RIV/00216208:11150/15:10295083 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0899900714001506" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0899900714001506</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.nut.2014.03.016" target="_blank" >10.1016/j.nut.2014.03.016</a>
Alternative languages
Result language
angličtina
Original language name
Ammonia and amino acid profiles in liver cirrhosis: Effects of variables leading to hepatic encephalopathy
Original language description
In the article is demonstrated that the main source of ammonia in cirrhotic subjects is activated breakdown of glutamine (GLN) in enterocytes and the kidneys and the main source of GLN is ammonia detoxification to GLN in the brain and skeletal muscle. The branched-chain amino acids (BCAA; valine, leucine, and isoleucine) decrease due to activated GLN synthesis in muscle. Aromatic amino acids (AAA; phenylalanine, tyrosine, and tryptophan) and methionine increase due to portosystemic shunts and reduced ability of diseased liver. It is concluded that (1) neither ammonia nor amino acid concentrations correlate closely with the severity of liver disease; (2) BCAA/AAA ratio could be used as a good index of liver impairment and for early detection of derangements in amino acid metabolism; and (3) variables potentially leading to overt encephalopathy exert substantial but uneven effects.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nutrition
ISSN
0899-9007
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
14-20
UT code for WoS article
000346685600002
EID of the result in the Scopus database
2-s2.0-84922252345