Synthesis, characterization and cytotoxic effect of vanadocene complexes bearing substituted 2,2 '-bipyridines and 4,5-diazafluoren-9-one
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10313730" target="_blank" >RIV/00216208:11150/15:10313730 - isvavai.cz</a>
Alternative codes found
RIV/00216275:25310/15:39899625
Result on the web
<a href="http://dx.doi.org/10.1016/j.ica.2014.12.021" target="_blank" >http://dx.doi.org/10.1016/j.ica.2014.12.021</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ica.2014.12.021" target="_blank" >10.1016/j.ica.2014.12.021</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis, characterization and cytotoxic effect of vanadocene complexes bearing substituted 2,2 '-bipyridines and 4,5-diazafluoren-9-one
Original language description
This study describes the synthesis of vanadocene compounds [Cp'2V(L)][OTf]2, where Cp' is substituted cyclopentadienyl ring and L is N,N-chelating ligand. All prepared compounds were characterized by analytical and spectroscopic methods. The structures of [(?5-C5H4Me)2V(bpy)][OTf]2, [(?5-C5H4iPr)2V(bpy)][OTf]2.CH2Cl2, [Cp2V(4,4'-Me2-bpy)][OTf]2, [Cp2V{4,4'-(MeO)2-bpy}][OTf]2.MeOH and [(?5-C5H4Me)2V(dafone)][OTf]2 were further confirmed by the X-ray diffraction analysis. The cytotoxicity study, performedon human leukemia cells MOLT-4 and HL-60, demonstrates that the activity of the vanadocene complexes strongly depends on the nature of the coordinated chelating ligand. The high cytotoxicity was observed for the complex bearing 2,2'-bipyridine, [(?5-C5H4Me)2V(bpy)][OTf]2, that shows IC50 values close to the data observed for cisplatin.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inorganica Chimica Acta
ISSN
0020-1693
e-ISSN
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Volume of the periodical
427
Issue of the periodical within the volume
March
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
211-218
UT code for WoS article
000349462500029
EID of the result in the Scopus database
2-s2.0-84921350925