Can Substitution of Chlorides Enhance the Cytotoxicity of Vanadocene Dichloride?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F13%3A39896348" target="_blank" >RIV/00216275:25310/13:39896348 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/13:10138938
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/ejic.201201505/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/ejic.201201505/abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejic.201201505" target="_blank" >10.1002/ejic.201201505</a>
Alternative languages
Result language
angličtina
Original language name
Can Substitution of Chlorides Enhance the Cytotoxicity of Vanadocene Dichloride?
Original language description
A series of vanadocene complexes [Cp2V(L)][OTf]2 (Cp = 5-C5H5, 5-C5H4Me; L = phen, 5-NO2-phen, 5-NH2-phen, 4,7-Ph2-phen) was prepared and characterized by mass spectrometry and EPR spectroscopy. Structures of two complexes that contain an N,N-chelating ligand, [(5-C5H4Me)2V(phen)][OTf]2.0.5Me2CO and [(5-C5H5)2V(5-NH2-phen)][OTf]2, and the triflate intermediate [(5-C5H5)2V(OTf)2] were further confirmed by X-ray diffraction analysis. The cytotoxicity study has shown that complexes that contain phenanthroline ligands have considerably higher in vitro activity toward human leukemia cells MOLT-4 and HL-60 than their parent dichlorides ([Cp2VCl2]). The high activity of these complexes coheres with their higher stability in various aqueous media. This study has further shown that substitution of chloride ligands in the vanadocene dichloride has a considerably higher effect on cytotoxicity than expected on the basis of established mechanistic rules.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Inorganic Chemistry
ISSN
1434-1948
e-ISSN
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Volume of the periodical
2013
Issue of the periodical within the volume
14
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
2665-2672
UT code for WoS article
000318510300022
EID of the result in the Scopus database
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