Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10315660" target="_blank" >RIV/00216208:11150/15:10315660 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3390/ijms16024043" target="_blank" >http://dx.doi.org/10.3390/ijms16024043</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms16024043" target="_blank" >10.3390/ijms16024043</a>

Result language

angličtina

Original language name

Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine

Original language description

Stem cells are unique pools of cells that are crucial for embryonic development and maintenance of adult tissue homeostasis. The landmark Nobel Prize winning research by Yamanaka and colleagues to induce pluripotency in somatic cells has reshaped the field of stem cell research. The complications related to the usage of pluripotent embryonic stem cells (ESCs) in human medicine, particularly ESC isolation and histoincompatibility were bypassed with induced pluripotent stem cell (iPSC) technology. The human iPSCs can be used for studying embryogenesis, disease modeling, drug testing and regenerative medicine. iPSCs can be diverted to different cell lineages using small molecules and growth factors. In this review we have focused on iPSC differentiation towards cardiac and neuronal lineages. Moreover, we deal with the use of iPSCs in regenerative medicine and modeling diseases like myocardial infarction, Timothy syndrome, dilated cardiomyopathy, Parkinson's, Alzheimer's and Huntington's d

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

—

Volume of the periodical

16

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

25

Pages from-to

4043-4067

UT code for WoS article

000350333600108

EID of the result in the Scopus database

2-s2.0-84922948612