The Importance of Wireless Capsule Endoscopy for Research into the Intestin Absorption Window of 5-Aminosalicylic Acid in Experimental Pigs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10362974" target="_blank" >RIV/00216208:11150/17:10362974 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/17:10362974 RIV/00179906:_____/17:10362974

Result on the web

<a href="http://www.eurekaselect.com/147859" target="_blank" >http://www.eurekaselect.com/147859</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1381612822666161201145247" target="_blank" >10.2174/1381612822666161201145247</a>

Result language

angličtina

Original language name

The Importance of Wireless Capsule Endoscopy for Research into the Intestin Absorption Window of 5-Aminosalicylic Acid in Experimental Pigs

Original language description

Background: Absorption windows in particular segments of the small intestine can contribute to the development of orally administered drug formulations and can limit the bioavailability of released compounds. Objective: The aim of this study was to evaluate use of wireless capsule enteroscopy regarding the disintegration kinetic process of tablets in the small intestine and its comparison with the levels of the model drug (5-aminosalicylic acid; 5-ASA), and its majority metabolite (N-acetyl-5-aminosalicylic acid; N-acetyl-5-ASA) in blood plasma. Methods: Tablets were endoscopically introduced into the duodenum and their disintegration was monitored using wireless capsule enteroscopy in anaesthetised pigs. In parallel, blood plasma time profiles of the model drug (5-ASA) released from tablets and its metabolite (N-acetyl-5-ASA) were detected. Results: The disintegration of tablets was evident in the proximal jejunum (until the 90-minute mark) and culminated at the 3rd hour. The maximum plasmatic concentration of 5-ASA was reached at the 3rd hour and in the case of its metabolite (N-acetyl-5-ASA) at the 4th hour. Conclusion: The study demonstrated the advantage of combination of wireless capsule enteroscopy and bioanalytical determination of pharmacokinetic parameters in an animal experiment to localise the disintegration site of solid dosage form and following kinetics of intestinal absorption of the released active agent.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30219 - Gastroenterology and hepatology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Pharmaceutical Design

ISSN

1381-6128

e-ISSN

—

Volume of the periodical

23

Issue of the periodical within the volume

12

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

4

Pages from-to

1873-1876

UT code for WoS article

000401433500015

EID of the result in the Scopus database

2-s2.0-85020807857