Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10365828" target="_blank" >RIV/00216208:11150/17:10365828 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/17:10365828
Result on the web
<a href="http://dx.doi.org/10.1080/15622975.2016.1268715" target="_blank" >http://dx.doi.org/10.1080/15622975.2016.1268715</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15622975.2016.1268715" target="_blank" >10.1080/15622975.2016.1268715</a>
Alternative languages
Result language
angličtina
Original language name
Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics
Original language description
Objectives: Schizophrenia is a severe psychiatric disease affecting about 1% of the general population. The relative contribution of genetic factors has been estimated to be up to 80%. The mode of inheritance is complex, non-Mendelian, and in most cases involving the combined action of large numbers of genes.Methods: This review summarises recent efforts to identify genetic variants associated with schizophrenia detected, e.g., through genome-wide association studies, studies on copy-number variants or next-generation sequencing.Results: A large, new body of evidence on genetics of schizophrenia has accumulated over recent years. Many new robustly associated genetic loci have been detected. Furthermore, there is consensus that at least a dozen microdeletions and microduplications contribute to the disease. Genetic overlap between schizophrenia, other psychiatric disorders, and neurodevelopmental syndromes raised new questions regarding the current classification of psychiatric and neurodevelopmental diseases.Conclusions: Future studies will address especially the functional characterisation of genetic variants. This will hopefully open the doors to our understanding of the pathophysiology of schizophrenia and other related diseases. Complementary, integrated systems biology approaches to genomics, transcriptomics, proteomics and metabolomics may also play crucial roles in enabling a precision medicine approach to the treatment of individual patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
World Journal of Biological Psychiatry
ISSN
1562-2975
e-ISSN
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Volume of the periodical
18
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
492-505
UT code for WoS article
000410902200002
EID of the result in the Scopus database
2-s2.0-85010686603