Association of peripheral blood cell count-derived ratios, biomarkers of inflammatory response and tumor growth with outcome in previously treated metastatic colorectal carcinoma patients receiving cetuximab
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10368173" target="_blank" >RIV/00216208:11150/17:10368173 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/17:10368173 RIV/00179906:_____/17:10368173 RIV/61989592:15110/17:73583798 RIV/61989592:15310/17:73583798
Result on the web
<a href="http://www.degruyter.com/view/j/pteridines.2017.28.issue-3-4/pterid-2017-0016/pterid-2017-0016.xml" target="_blank" >http://www.degruyter.com/view/j/pteridines.2017.28.issue-3-4/pterid-2017-0016/pterid-2017-0016.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/pterid-2017-0016" target="_blank" >10.1515/pterid-2017-0016</a>
Alternative languages
Result language
angličtina
Original language name
Association of peripheral blood cell count-derived ratios, biomarkers of inflammatory response and tumor growth with outcome in previously treated metastatic colorectal carcinoma patients receiving cetuximab
Original language description
The aim of the present study was to investigate the association of peripheral-blood cell count (PBC)-derived ratios, other biomarkers of inflammation and biomarkers of tumor growth with outcome in a cohort of patients presenting for the next line of therapy after the failure of prior systemic treatment. The data of 51 patients with advanced/metastatic colorectal carcinoma treated with cetuximab in the second or higher line of therapy were retrospectively analyzed. The median duration of cetuximab therapy and the median survival were 5.1 and 12.1 months, respectively. C-reactive protein (CRP), but not urinary neopterin correlated significantly with PBC-derived ratios. Both CRP and urinary neopterin correlated positively with carcinoembryonic antigen (CEA) concentrations and biomarkers of liver dysfunction. Although a number of parameters predicted overall survival in univariate analysis, only hemoglobin, CEA change and serum bilirubin were independent predictors of survival. In conclusion, in patients with metastatic colorectal carcinoma and predominantly liver metastases, the outcome of therapy in the advanced line setting was associated with initial hemoglobin level, a decrease of CEA concentration and initial presence of liver dysfunction. Urinary neopterin did not correlate with PBC-derived ratios, in contrast to CRP, but both urinary neopterin and serum CRP concentrations correlated with laboratory parameters of liver dysfunction.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/NV16-32198A" target="_blank" >NV16-32198A: Genetic and epigenetic predictive biomarkers of treatment success for angiogenesis inhibitors in colorectal carcinoma</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pteridines
ISSN
0933-4807
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
3-4
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
221-232
UT code for WoS article
000416827700013
EID of the result in the Scopus database
2-s2.0-85037850210