Flubendazole induces mitotic catastrophe and apoptosis in melanoma cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10377027" target="_blank" >RIV/00216208:11150/18:10377027 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/18:10377027
Result on the web
<a href="https://doi.org/10.1016/j.tiv.2017.10.025" target="_blank" >https://doi.org/10.1016/j.tiv.2017.10.025</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tiv.2017.10.025" target="_blank" >10.1016/j.tiv.2017.10.025</a>
Alternative languages
Result language
angličtina
Original language name
Flubendazole induces mitotic catastrophe and apoptosis in melanoma cells
Original language description
Flubendazole (FLU) is a widely used anthelmintic drug belonging to benzimidazole group. Recently, several studies have been published demonstrating its potential to inhibit growth of various tumor cells including those derived from colorectal cancer, breast cancer or leukemia via several mechanisms. In the present study we have investigated cytotoxic effects of FLU on malignant melanoma using A-375, BOWES and RPMI-7951 cell lines representing diverse melanoma molecular types. In all three cell lines, FLU inhibited cell growth and proliferation and disrupted microtubule structure and function which was accompanied by dramatic changes in cellular morphology. In addition, FLU-treated cells accumulated at the G2/M phase of cell cycle and displayed the features of mitotic catastrophe characterized by formation of giant cells with multiple nuclei, abnormal spindles and subsequent apoptotic demise. Although this endpoint was observed in all treated melanoma lines, our analyses showed different activated biochemical signaling in particular cells, thus suggesting a promising treatment potential of FLU in malignant melanoma warranting its further testing.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology in Vitro
ISSN
0887-2333
e-ISSN
—
Volume of the periodical
46
Issue of the periodical within the volume
February
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
313-322
UT code for WoS article
000422811300036
EID of the result in the Scopus database
2-s2.0-85033399921