Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F13%3A10159264" target="_blank" >RIV/00216208:11150/13:10159264 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/13:10159264
Result on the web
<a href="http://journals.lww.com/anti-cancerdrugs/Abstract/2013/10000/Antiproliferative_effect_of_benzimidazole.5.aspx" target="_blank" >http://journals.lww.com/anti-cancerdrugs/Abstract/2013/10000/Antiproliferative_effect_of_benzimidazole.5.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/CAD.0b013e3283648c69" target="_blank" >10.1097/CAD.0b013e3283648c69</a>
Alternative languages
Result language
angličtina
Original language name
Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines
Original language description
This study aimed to test the antiproliferative effect of three benzimidazole anthelmintics in intestinal cancer cells and to investigate whether these drugs, which inhibit tubulin polymerization, can potentiate the efficacy of the microtubule-stabilizingdrug paclitaxel (PTX). Four intestinal cancer cell lines, SW480, SW620, HCT8, and Caco2, with different origins and growth characteristics were used. The antiproliferative effect of albendazole (ABZ), ricobendazole (RBZ), flubendazole (FLU), and their combinations with PTX was tested using three different end-point viability assays, cell cycle distribution analysis, and the x-CELLigence System for real-time cell analysis. ABZ and FLU inhibited cell proliferation significantly in a concentration-dependent and time-dependent manner through cell arrest in the G2/M phase. RBZ was not effective at any concentration tested. The cell lines differed in sensitivity to FLU and ABZ, with HCT8 being the most sensitive, showing IC50 values for ABZ
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anti-Cancer Drugs
ISSN
0959-4973
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
911-919
UT code for WoS article
000323885000005
EID of the result in the Scopus database
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