Neopterin, kynurenine and tryptophan as new biomarkers for early detection of rectal anastomotic leakage

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10381047" target="_blank" >RIV/00216208:11150/18:10381047 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/18:43889439 RIV/00216208:11160/18:10381047 RIV/00179906:_____/18:10381047

Result on the web

<a href="http://www.termedia.pl/,42,31770,1,1.html" target="_blank" >http://www.termedia.pl/,42,31770,1,1.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/wiitm.2018.73363" target="_blank" >10.5114/wiitm.2018.73363</a>

Result language

angličtina

Original language name

Neopterin, kynurenine and tryptophan as new biomarkers for early detection of rectal anastomotic leakage

Original language description

Introduction: At present, there are no strong predictors, nor a useful scoring system, that clearly identifies patients at risk for anastomotic leakage. Aim: This study aimed to investigate a new method that assesses this risk by monitoring levels of neopterin, tryptophan, and kynurenine, in bodily fluids. Material and methods: This prospective study included patients who underwent elective rectal resection for carcinoma. The basic condition for inclusion was rectal anastomosis using the double-stapling technique. Preoperative levels of neopterin, tryptophan, kynurenine, and their ratios, were assessed with blood and urine samples. These levels were then monitored for 6 postoperative days in venous blood, urine, and abdominal drainage fluid. Results: A total of 42 patients were enrolled in the study. Thirty-six patients underwent a laparoscopic resection and 6 patients had an open procedure. No differences were found among neopterin, tryptophan, and kynurenine serum levels. However, the groups were observed to have significant differences in the urinary neopterin/creatinine ratio: the preoperative neopterin/creatinine ratio was 139.5 mu mol/mol in the group with leakage, vs 114.8 mu mol/mol in the group without complications, p = 0.037. The same results were observed during the postoperative period, p = 0.012. Additionally, the group with complications had a higher mean value of neopterin in drainage fluid, p = 0.048. Conclusions: Our study demonstrated that high preoperative levels of urinary neopterin could be interpreted as a risk for anastomotic leakage. Moreover, pathological levels of neopterin in urine and abdominal drainage fluid could be useful for early identification of anastomotic leakage during the postoperative period prior to its clinical development.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30212 - Surgery

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Videosurgery and Other Miniinvasive Techniques

ISSN

1895-4588

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

1

Country of publishing house

PL - POLAND

Number of pages

9

Pages from-to

44-52

UT code for WoS article

000427958500006

EID of the result in the Scopus database

2-s2.0-85044428654