Concentrations of neopterin, kynurenine and tryptophan in wound secretions of patients with breast cancer and malignant melanoma: a pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25520%2F17%3A39912129" target="_blank" >RIV/00216275:25520/17:39912129 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/17:10367923 RIV/00179906:_____/17:10367923 RIV/61989592:15110/17:73583817

Result on the web

<a href="http://dx.doi.org/10.1515/pterid-2017-0018" target="_blank" >http://dx.doi.org/10.1515/pterid-2017-0018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/pterid-2017-0018" target="_blank" >10.1515/pterid-2017-0018</a>

Result language

angličtina

Original language name

Concentrations of neopterin, kynurenine and tryptophan in wound secretions of patients with breast cancer and malignant melanoma: a pilot study

Original language description

The aim of the present pilot study was to investigate the concentrations of neopterin, kynurenine and tryptophan in wound secretion in patients undergoing surgery for breast cancer or malignant melanoma. Twenty-two patients, 16 females and 6 males, undergoing surgery for breast cancer (n = 15) or malignant melanoma (n = 7) were evaluated. Neopterin, kynurenine and tryptophan were determined using a high-performance liquid chromatography method. When the concentrations in wound secretions from the primary breast tumor and the axilla were compared, the neopterin/tryptophan ratio was significantly higher in the tumor wound secretions (0.92 +/- 0.41 vs. 0.61 +/- 0.14 mmol/mol; p = 0.049), but no significant differences were observed in neopterin (49.2 +/- 28.6 vs. 31.5 +/- 11.1 nmol/L), tryptophan (52.9 +/- 13.0 vs. 51.2 +/- 13.3 mu mol/L) and kynurenine concentrations 5.97 +/- 7.49 vs. 5.34 +/- 6.25 mu mol/L) and kynurenine/tryptophan ratio (108.1 +/- 107.7 vs. 103.5 +/- 106.7 mmol/mol). No marked differences were noted in neopterin, tryptophan and kynurenine concentrations and kynurenine/tryptophan and neopterin/tryptophan ratios in sequential samples from the axilla of breast cancer patients obtained on days 1 and 2. In conclusion, present data demonstrate that the measurement of neopterin, kynurenine and tryptophan can be used to monitor local immune response after cancer surgery.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30212 - Surgery

Project

<a href="/en/project/NV16-32030A" target="_blank" >NV16-32030A: Repurposing disulfiram as a novel treatment for chemo-endocrine therapy-resistant, recurrent metastatic breast cancer</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pteridines

ISSN

0933-4807

e-ISSN

—

Volume of the periodical

28

Issue of the periodical within the volume

3-4

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

205-211

UT code for WoS article

000416827700011

EID of the result in the Scopus database

2-s2.0-85037864177