Cardiac doses of accelerated partial breast irradiation with perioperative multicatheter interstitial brachytherapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F21%3A10423515" target="_blank" >RIV/00216208:11150/21:10423515 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/21:10423515

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-TIZBTfF4I" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-TIZBTfF4I</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00066-020-01699-5" target="_blank" >10.1007/s00066-020-01699-5</a>

Result language

angličtina

Original language name

Cardiac doses of accelerated partial breast irradiation with perioperative multicatheter interstitial brachytherapy

Original language description

Purpose To quantify mean heart dose (MHD) and doses to the left anterior descending artery (LAD) and left ventricle (LV) in a retrospective series of patients who underwent perioperative accelerated partial breast irradiation with multicatheter interstitial brachytherapy (MIB-APBI). Methods Sixty-eight patients with low-risk left breast cancer were treated with MIB-APBI at our institution between 2012 and 2017. Interstitial tubes were inserted during the tumorectomy and sentinel node biopsy and APBI was started 6 days later. The prescribed dose was 34Gy in 10 fractions (twice a day) to the clinical target volume (CTV). The heart, LAD, and LV were contoured and the distance between each structure and the CTV was measured. The MHD, mean and maximum LAD doses (LAD mean/max), and mean LV doses (LV mean) were calculated and corrected to biologically equivalent doses in 2-Gy fractionation (EQD2). We also evaluated the impact of the distance between the cardiac structures and the CTV and of the volume receiving the prescribed dose (V100) and high-dose volume (V150) on heart dosimetry. Results Mean EQD2 for MHD, LAD mean/max, and mean LV were 0.9 +/- 0.4Gy (range 0.3-2.2), 1.6 +/- 1.1Gy (range, 0.4-5.6), 2.6 +/- 1.9Gy (range, 0.7-9.2), and 1.3 +/- 0.6Gy (range, 0.5-3.4), respectively. MHD, LAD mean/max, and LV mean significantly correlated with the distance between the CTV and these structures, but all doses were below the recommended limits (German Society of Radiation Oncology; DEGRO). The MHD and LV mean were significantly dependent on V100. Conclusion Perioperative MIB-APBI resulted in low cardiac doses in our study. This finding provides further support for the value of this technique in well-selected patients with early-stage left breast cancer.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Strahlentherapie und Onkologie

ISSN

0179-7158

e-ISSN

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Volume of the periodical

197

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

288-295

UT code for WoS article

000579308100001

EID of the result in the Scopus database

2-s2.0-85092675167