Pregnancy in homozygous familial hypercholesterolemia-A case series
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F22%3A10454374" target="_blank" >RIV/00216208:11150/22:10454374 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/22:10454374
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3EU~.6xvtJ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3EU~.6xvtJ</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/1744-9987.13841" target="_blank" >10.1111/1744-9987.13841</a>
Alternative languages
Result language
angličtina
Original language name
Pregnancy in homozygous familial hypercholesterolemia-A case series
Original language description
IntroductionFamilial hypercholesterolemia (FH) is an autosomal codominant lipid metabolism disorder. It results in lifelong elevation of plasmatic low-density lipoprotein cholesterol (LDL-C) levels, followed by premature atherosclerosis. In women, pregnancy and lactation represent an additional risk due to association of physiological changes, pre-existing dyslipidemia, and limited therapeutic possibilities and experiences. Methods of extracorporeal LDL-apheresis represent a suitable therapeutic approach. Case seriesWe present our experience in case reports of six HoFH women and their 13 pregnancies (nine successful, three abortions, and one interruption). One patient experienced a lethal complication of her pregnancy. Of the nine successful pregnancies, two cases were treated by LDL-apheresis. ConclusionPregnancy in HoFH women represents substantial risk; however, patients without signs of decompensated cardiovascular disease can have a good prognosis. LDL-apheresis plays an important role in the management of pregnancy in HoFH.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/NV17-28882A" target="_blank" >NV17-28882A: Genetic plymorphisms, MicroRNAs and bioindicators of activity: interrelations in the diagnostics and therapy of severe familial hypercholesterolemia</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Therapeutic Apheresis and Dialysis
ISSN
1744-9979
e-ISSN
1744-9987
Volume of the periodical
26
Issue of the periodical within the volume
Suppl. 1
Country of publishing house
JP - JAPAN
Number of pages
8
Pages from-to
89-96
UT code for WoS article
000896663600001
EID of the result in the Scopus database
2-s2.0-85143893405