Could oxime HI-6 really be considered as 'broad-spectrum' antidote?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F09%3A00210077" target="_blank" >RIV/00216208:11160/09:00210077 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/09:00002213
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Could oxime HI-6 really be considered as 'broad-spectrum' antidote?
Original language description
The broad-spectrum reactivator is a valuable oxime able to reactivate acetylcholinesterase (AChE) inhibited by nerve agents and pesticides. At present there are many AChE reactivators (oximes) which are suitable candidates as broad-spectrum reactivatorsand among them is the oxime HI-6, highly enough thought of to have been recommended by many armies for use as a universal antidote. In this study, we wanted to establish whether the designation 'broad-spectrum' is a an accurate description or if there are some lacks in reactivation of nerve agents or pesticides. For this purpose, the general in vitro test for the evaluation of AChE reactivators was used. Tabun, sarin, cyclosarin, soman, VX agent, Russian VX were used as nerve agents for testing, and chlorpyrifos, paraoxon, methyl-chlorpyrifos and dichlorvos (DDVP) were used as typical examples of organophoshorus pesticides. The results obtained showed that oxime HI-6 did not reactivate tabun- and DDVP-inhibited AChE, and, in the case of
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP305%2F07%2FP162" target="_blank" >GP305/07/P162: Relationship between structure of acetylcholinesterase reactivators and their reactivation potency</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Applied Biomedicine
ISSN
1214-0287
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
7
Pages from-to
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UT code for WoS article
000270462000005
EID of the result in the Scopus database
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