Synthesis and in vitro evaluation of new tacrine derivatives - bis-alkylene linked 7-MEOTA

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F10%3A00300599" target="_blank" >RIV/00216208:11160/10:00300599 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Synthesis and in vitro evaluation of new tacrine derivatives - bis-alkylene linked 7-MEOTA

Original language description

Formely, 7-MEOTA was investigated as promising tacrine analogue beneficial for its low toxicicity compared to tacrine. In this study bis-alkylene linked 7-MEOTA derivatives were prepared from 7-MEOTA and corresponding diiodoalkanes. The novel compounds exhibit anticholinesterase (anti-AChE nad anti-BChE) activity in vitro.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Letters in Organic Chemistry

ISSN

1570-1786

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

4

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

5

Pages from-to

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UT code for WoS article

000277156500011

EID of the result in the Scopus database

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