Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F10%3A00002297" target="_blank" >RIV/60162694:G44__/10:00002297 - isvavai.cz</a>

Alternative codes found

RIV/44555601:13440/10:00005558

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA

Original language description

Formerly, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA) was investigated as promising tacrine analogue beneficial for its low toxicity compared to tacrine. In this study, novel 7-MEOTA derivatives were synthesized - namely - 9,9`-di-(alkane-1,omega-diyldiimino)-di-(7-methoxy-1,2,3,4-tetrahydroacridine) was prepared from the corresponding diiodoalkanes. The novel compounds exhibit anticholinesterase (acetylcholinesterase and butyrylcholinesterase) activity in vitro. The synthesis and in vitro data are summarized in this article.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/OVUOFVZ200805" target="_blank" >OVUOFVZ200805: Novel inhibitors of acetylcholinesterase as prophylaxis of nerve agent poisonings</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Letters in Organic Chemistry

ISSN

1570-1786

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

4

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

5

Pages from-to

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UT code for WoS article

000277156500011

EID of the result in the Scopus database

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