Novel acetylcholinesterase reactivator - oxime K048 - reactivation activity in vitro

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F10%3A00300609" target="_blank" >RIV/00216208:11160/10:00300609 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/10:00002236

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Novel acetylcholinesterase reactivator - oxime K048 - reactivation activity in vitro

Original language description

Bispyridinium aldoxime K048 proved to be a promising antidote against tabun poisoning. In the present study, the oxime was tested against nine different AChE inhibitors using in vitro tests on rat brain homogenate as the source of the enzyme. The resultsshowed that K048 reached promising reactivation activity in case of all AChE inhibitors except cyclosarin, at oxime concentration 10E-3 M. At the concentration of 10E-5 M, which is more common for human use, only methylchlorpyrifos-inhibited AChE was reactivated.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/GP305%2F07%2FP162" target="_blank" >GP305/07/P162: Relationship between structure of acetylcholinesterase reactivators and their reactivation potency</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medicinal Chemistry

ISSN

1573-4064

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

1

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

5

Pages from-to

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UT code for WoS article

000276405800001

EID of the result in the Scopus database

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