The Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases - in vitro study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F07%3A00001812" target="_blank" >RIV/60162694:G44__/07:00001812 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases - in vitro study
Original language description
Intoxications caused by tabun nerve agent are generally very hard to treat by convential acetylcholinesterase (AChE) reactivators. Due to this, new AChE reactivators are still developed. In this study, we have tested three new promising bisquaternary AChE reactivators: K027, K033 and K048. These reactivators were previously tested on rat brain homogenate. To mimic reality, we studied the potency of these new oximes to reactivate tabun-inhibited human brain cholinesterases. As is evident from the results, reactivator K048 (reactivation 40%) surpassed all reactivators tested in this study [including the most promising ones, namely trimedoxime (37%) and obidoxime (33%)]. Moreover, if compared to our previous results from rat brain studies, species differences were demonstrated.
Czech name
Biskvarterní oximy jakožto reaktivátory tabunem-inhibované lidské cholinesterázy - in vitro studie
Czech description
Byla reaktivována tabunem-inhibovaná lidská AChE.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
<a href="/en/project/OPUOFVZ200603" target="_blank" >OPUOFVZ200603: A new method of prophylaxis, decontamination, diagnostics and therapy afer intoxication with nerve agents and yperits</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Basic and Clinical Pharmacology and Toxicology
ISSN
1742-7835
e-ISSN
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Volume of the periodical
101
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
25-28
UT code for WoS article
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EID of the result in the Scopus database
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