Circumventing the requirement of binding saturation for receptor quantification using interaction kinetic extrapolation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F11%3A10118908" target="_blank" >RIV/00216208:11160/11:10118908 - isvavai.cz</a>
Result on the web
<a href="http://ovidsp.tx.ovid.com/sp-3.5.1a/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&AN=00006231-201109000-00015&NEWS=N" target="_blank" >http://ovidsp.tx.ovid.com/sp-3.5.1a/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&AN=00006231-201109000-00015&NEWS=N</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MNM.0b013e3283483e1c" target="_blank" >10.1097/MNM.0b013e3283483e1c</a>
Alternative languages
Result language
angličtina
Original language name
Circumventing the requirement of binding saturation for receptor quantification using interaction kinetic extrapolation
Original language description
Quantification of the number of receptors per cell (NRPC) is important when assessing whether a tumor surface biomarker is suitable for medical imaging. One common method for NPRC quantification is to use a binding saturation assay, which is time consuming and requires large amounts of reagents. The aim of this study was to evaluate an alternative method based on kinetic extrapolation (KEX) and compare it with the classical manual saturation technique with regard to accuracy as well as time and reagentconsumption. From the observations described in this study, we believe that the KEX method enables fast, credible, and easy NRPC quantification with a reduction in reagent consumption.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nuclear Medicine Communications
ISSN
0143-3636
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
863-867
UT code for WoS article
000294345300015
EID of the result in the Scopus database
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