Different Radioactivity Uptake between Somatostatin Analogues Labelled with In-111 and Y-90/88 in Rat Kidney

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10124209" target="_blank" >RIV/00216208:11160/12:10124209 - isvavai.cz</a>

Result on the web

<a href="http://ar.iiarjournals.org/content/32/3/815.full" target="_blank" >http://ar.iiarjournals.org/content/32/3/815.full</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Different Radioactivity Uptake between Somatostatin Analogues Labelled with In-111 and Y-90/88 in Rat Kidney

Original language description

Somatostatin receptor targeting is a valuable method to treat somatostatin receptor-positive tumours. In peptide receptor radionuclide therapy, it is essential to determine the highest activity that can be safely administered to the patient. As Y-90 emits no gamma rays, absorbed doses for Y-90 are usually estimated using the same peptide labelled with In-111. The aim of the study was to determine if replacement of Y-90/88 by In-111 affects the biodistribution profile of five selected somatostatin analogues in preclinical experiments. Materials and Methods: Radiolabelled peptides were atministered in to male Wistar rats. Results: The peptides under studs, labelled either with In-111 or with Y-88/90 showed similar distribution profiles in all tissues excepting the kidney. The kidney radioactivity uptake was significantly lower for Y-88/90-labeled peptide in comparison with the one of In-111. Conclusion: We conclude that a radiation-absorbed dose after Y-90-labelled somatostatin analogues

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

3

Country of publishing house

GR - GREECE

Number of pages

8

Pages from-to

815-822

UT code for WoS article

000301619200017

EID of the result in the Scopus database

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