Receptor Affinity and Preclinical Biodistribution of Radiolabeled Somatostatin Analogs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10124213" target="_blank" >RIV/00216208:11160/12:10124213 - isvavai.cz</a>

Result on the web

<a href="http://ar.iiarjournals.org/content/32/3/761.full" target="_blank" >http://ar.iiarjournals.org/content/32/3/761.full</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Receptor Affinity and Preclinical Biodistribution of Radiolabeled Somatostatin Analogs

Original language description

In this study, we investigated the relationship between affinity to somatostatin receptor subtype2 (SSTR2) and uptake of radioactivity from a group of radiolabeled somatostatin analogues in somatostatin receptor-rich tissues of rats. Organs with a high density of somatostin receptors (namely the adrenals and pancreas bearing mainly SSTR2; this receptor subtype is also the most abundant in somatostatin receptor-positive tumors) were chosen as markers of specific binding of the peptides in vivo. Accumulations of radioactivity in these organs 24 h and 48 h after intravenous administration of six In-111-labeled octreotide and octreotate derivatives with predominant affinity to SSTR2 were correlated with affinity to SSTR2, determined in vitro (IC50 values).For correlation between adrenal uptake of radioactivity and IC50, the best fit for exponential dependence was found; for that of pancreas, however, linear dependence was the most suitable. In cases where the values for the peptide with a

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

3

Country of publishing house

GR - GREECE

Number of pages

6

Pages from-to

761-766

UT code for WoS article

000301619200007

EID of the result in the Scopus database

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