Preclinical pharmacokinetics of radiolabelled hyaluronan

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10124217" target="_blank" >RIV/00216208:11160/12:10124217 - isvavai.cz</a>

Result on the web

<a href="http://rabbit.if-pan.krakow.pl/pjp/pdf/2012/2_428.pdf" target="_blank" >http://rabbit.if-pan.krakow.pl/pjp/pdf/2012/2_428.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Preclinical pharmacokinetics of radiolabelled hyaluronan

Original language description

Background: Hyaluronan (HYA) is a high molecular weight glucosaminoglycan with a great perspective for medical applications. Because HYA is widespread in the body, it is difficult to determine the fate of exogenously administered HYA. Methods: In this study, HYA of different molecular weights (0.1-1 MDa) was labelled with Tc-99m, and the distribution profiles were determined after administrating the HYA to rats. Results: After the intravenous administration of Tc-99m-HYA, a rapid decrease in the radioactivity of blood samples was observed, presumably because of Tc-99m-HYA uptake by the liver; only minimal signs of liver radioactivity washout were detected. After the oral administration of Tc-99m-HYA, no significant absorption to the central compartmentwas found. A preliminary study using C-14-HYA exhibited a different distribution profile than Tc-99m-HYA because of the different administered dose and the fate of the degradation products. Even with C-14-HYA, only traces of radioactivit

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmacological Reports

ISSN

1734-1140

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

2

Country of publishing house

PL - POLAND

Number of pages

10

Pages from-to

428-437

UT code for WoS article

000305546700023

EID of the result in the Scopus database

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