Metabolic disposition and excretion of quinocetone in rats, pigs, broilers, and carp
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18450%2F14%3A50002640" target="_blank" >RIV/62690094:18450/14:50002640 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0278691514001860" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0278691514001860</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fct.2014.04.004" target="_blank" >10.1016/j.fct.2014.04.004</a>
Alternative languages
Result language
angličtina
Original language name
Metabolic disposition and excretion of quinocetone in rats, pigs, broilers, and carp
Original language description
Excretion, disposition, and metabolism of [H-3]-quinocetone in rats, pigs, broilers, and carp following oral administration were investigated. After a single p.o. dose, total radioactivity was rapidly excreted, with >= 94% in all species within 14 days.Fecal excretion of radioactivity was 68% and 65% of the administered dose in rats and pigs, respectively, with the remainder excreted in the urine. Six hours after the last of seven daily oral administrations of H-3-labeled QCT, radioactivity was found to be distributed throughout all tissues, with the majority of radioactivity cleared within 7 days, and elimination was the slowest from the liver and kidney. QCT was extensively metabolized in all of the species, and the primary changes included N-O group reduction, carbonyl group reduction, double bond reduction, and hydroxylation. The major tissue metabolites of QCT were Q2, Q4, Q5, Q8, and Q9 in rats; Q1, Q2, Q3, Q4, and Q5 in pigs; Q1, Q2, Q3, Q4, and Q7 in broilers; and Q1, Q2 in ca
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Food and chemical toxicology
ISSN
0278-6915
e-ISSN
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Volume of the periodical
69
Issue of the periodical within the volume
JUL
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
109-119
UT code for WoS article
000338817900015
EID of the result in the Scopus database
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