The Retention Behavior of Acidic, Basic and Neutral Pharmaceuticals on the Deactivated Polybutadiene Zirconia Phase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10124976" target="_blank" >RIV/00216208:11160/12:10124976 - isvavai.cz</a>
Result on the web
<a href="http://www.ingentaconnect.com/content/ben/cac/2012/00000008/00000004/art00018" target="_blank" >http://www.ingentaconnect.com/content/ben/cac/2012/00000008/00000004/art00018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/157341112803216726" target="_blank" >10.2174/157341112803216726</a>
Alternative languages
Result language
angličtina
Original language name
The Retention Behavior of Acidic, Basic and Neutral Pharmaceuticals on the Deactivated Polybutadiene Zirconia Phase
Original language description
Reversed zirconia-based stationary phases belong among interesting alternatives of widely used RP silica phases. Zirconia displays specific surface properties, which are responsible for a unique retention mechanism. Furthermore, especially for acidic analytes it is necessary to add a strong Lewis base to the mobile phase mainly to improve the separation efficiency. However, commonly recommended strong Lewis base buffers are not volatile and therefore are incompatible with a mass spectrometric detection.A novel RP zirconia-based stationary phase with deactivated Lewis acid sites of zirconia was introduced to enable the use of volatile additives (acetate, formate) despite their low Lewis basicity. It is reported on the influence of surface deactivationon chromatographic behaviour of acidic, basic and neutral analytes in this paper. The influence of variables such as pH levels, Lewis base type, its concentration and temperature were studied. The results were compared with the undeactiva
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Analytical Chemistry
ISSN
1573-4110
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
4
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
9
Pages from-to
574-582
UT code for WoS article
000308673900018
EID of the result in the Scopus database
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