Radiolabeling and biodistribution of new acetylcholinesterase inhibitor - 6-Hydrazino-IV-[5-(2,3-dihydro-1H-cyclopenta[b] quinolin-9-ylamino)pentyl] nicotinamide hydrochloride

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10133990" target="_blank" >RIV/00216208:11160/12:10133990 - isvavai.cz</a>

Result on the web

<a href="http://wydawnictwo.umlub.pl/pharmacy/en/artykul/szczegoly/id/3579" target="_blank" >http://wydawnictwo.umlub.pl/pharmacy/en/artykul/szczegoly/id/3579</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Radiolabeling and biodistribution of new acetylcholinesterase inhibitor - 6-Hydrazino-IV-[5-(2,3-dihydro-1H-cyclopenta[b] quinolin-9-ylamino)pentyl] nicotinamide hydrochloride

Original language description

Nowadays research concerning new strategies for earlier diagnosis is among the most active areas in Alzheimer's science. Brain imaging techniques are among the most promising areas of research focused on early detection of Alzheimer's disease (AD). In the present study we describe radiolabeling of a novel acetylcholinesterase inhibitor 6-hydrazino-N-[5-(2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamino)pentyl]nicotinamide (5C-5) with 99m-Technetium (99mTc). Biodistribution study of compound 5C-5 radiolabeled with 99mTc after intravenous administration to rats was also performed. According to biodistribution study 99mTc-radioactivity was mainly localized in the liver, partly also in the kidney, lung and gastrointestinal tract. Furthermore, compound under study revealed comparatively rapid blood radioactivity clearance.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/GAP304%2F10%2F1738" target="_blank" >GAP304/10/1738: Radiolabelled neuropeptides for cancer diagnosis and treatment</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia

ISSN

0867-0609

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

3

Country of publishing house

PL - POLAND

Number of pages

5

Pages from-to

294-298

UT code for WoS article

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EID of the result in the Scopus database

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